Medical term:

2,3-diphosphoglycerate

2,3-DPG

An inorganic phosphate produced in red cells by the Rapoport-Luebering shunt; 2,3-DPG binds to the beta chain of reduced haemoglobin (Hb), lowering Hb's affinity for O2 and by extension, facilitating O2 release to tissues, causing a "right shift" of the O2 dissociation curve. 2,3-DPG further shifts the curve to the right by lowering the red cells' pH, When transfused, red cells regain 50% of the 2,3-DPG within 3–8 hours and 100% within 24 hours.
Increased DPG High altitude, anaemia, chronic hypoxia, hyperthyroidism, chronic alkalosis
Decreased DPG Storage of blood, hypothyroidism, hypophosphatemia, acidosis

2,3-di·phos·pho·glyc·er·ate

(dī-fos'fō-glis'ĕr-āt)

An intermediate in the Rapoport-Luebering shunt, formed between 1,3-P₂Gri and 3-phosphoglycerate; an important regulator of the affinity of hemoglobin for oxygen; an intermediate of phosphoglycerate mutase.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

2,3-diphosphoglycerate

(dī″fŏs-fō-glĭs′ĕr-āt″),

2,3-DPG

An organic phosphate in red blood cells that alters the affinity of hemoglobin for oxygen. Blood cells stored in a blood bank lose 2,3-diphosphoglycerate, but once they are infused, the substance is resynthesized or reactivated.

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