Medical term:

dedifferentiate


anaplasia

 [an″ah-pla´zhah]
loss of differentiation of cells and their orientation to each other, a characteristic of tumor cells; called also dedifferentiation and undifferentiation.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

de·dif·fer·en·ti·a·tion

(dē-dif'ĕr-en'shē-ā'shŭn),
1. The return of parts to a more homogeneous state.
2. Synonym(s): anaplasia
Farlex Partner Medical Dictionary © Farlex 2012

dedifferentiation

(dē′dĭf-ə-rĕn′shē-ā′shən)
n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.
de′dif·fer·en′ti·ate′ v.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

dedifferentiation

Pathology
The reversion of a cell or cell line to a more embryonic form.
 
Tumour biology
The loss of the cellular features of terminal differentiation, a finding often associated with increased aggressiveness of a neoplasm.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

de·dif·fer·en·ti·a·tion

(dē-dif'ĕr-en'shē-ā'shŭn)
1. The return of parts to a more homogeneous state.
2. Synonym(s): anaplasia.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

dedifferentiation

a process in which tissues that have undergone CELL DIFFERENTIATION can be made to reverse the process so as to become a primordial cell again (see GURDON). In theory, all cells should possess this ability since the mature cell does not lose DNA (see TOTIPOTENCY), but reversal has been demonstrated in plants much more easily than in animal cells.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

dedifferentiated

Referring to a cell or tissue which has acquired a less mature appearance and metabolic profile, an event classically associated with aggressive malignancies.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

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