granulomatous

composed of granulomas.

An inflammatory response that results when macrophages are unable to destroy foreign substances that have entered or invaded body tissues. Large numbers of macrophages are drawn to the affected area over 7 to 10 days, surround the target, and enclose it. They in turn are surrounded by polymorphonuclear leukocytes, other immune cells, and fibroblasts. Granulomas are common in many conditions, including leprosy, tuberculosis, cat scratch disease, some fungal infections, and foreign body reactions, e.g., reactions to sutures. granulomatous (gran?yu-lo'ma-tus), adjective See: giant cell; tuberculosis; Wegener granulomatosis

A circular rash with a raised red border, usually found on the hands, knuckles, or arms of young patients. The cause is unknown. The rash often lasts 1 or 2 years and then may disappear spontaneously.

A lymphadenoma of the thyroid.

A chronic, generalized granuloma caused by the fungus Coccidioides immitis.

A granuloma developing at the tip of a tooth root, usually the result of pulpitis. It consists of a proliferating mass of chronic inflammatory tissue and possibly epithelial nests or colonies of bacteria. It may be encapsulated by fibrous tissue of the periodontal ligament.

A form of xanthomatosis accompanied by eosinophilia and the formation of cysts on bone.

A circumscribed, firm, fissured, fibrotic, benign tumor caused by chronic irritation. It may occur where hard objects such as dentures or the earpieces of glasses rub against the labioalveolar fold or the retroauricular fold. The tumor disappears when the irritating object is removed.

Chronic inflammation around foreign bodies such as sutures, talc, splinters, or gravel.

Any infectious disease in which granulomas are formed, e.g., tuberculosis or syphilis. Granulomas are also formed in mycoses and protozoan infections.

A granulomatous ulcerative disease in which the initial lesion commonly appears in the genital area as a painless nodule.

Etiology

This type of granuloma is caused by a short, gram-negative bacillus, Calymmatobacterium granulomatis, (“Donovan body”).

Treatment

Erythromycin, trimethoprim-sulfamethoxazole, or tetracyclines are used in treating this disease. Single-dose therapy with intramuscular ceftriaxone or oral ciprofloxacin may be effective.

A granuloma that develops on the iris.

A granuloma that contains fatty tissue or cholesterol.

A granuloma in which the macrophages have phagocytosed the surrounding fat cells.

A chronic skin infection caused by Mycobacterium marinum.

A very vascular granuloma at any site, but esp. in the nasal mucosa or pharynx.