Medical term:
polymixin
polymyxin
[pol″e-mik´sin]a generic term for antibiotics derived from various strains of Bacillus polymyxa, several closely related compounds being designated by letters.
polymyxin B a bacteriostatic and bactericidal antibiotic, effective mainly against gram-negative organisms. It is used as the sulfate salt, and is especially effective against Pseudomonas aeruginosa, which may cause septicemia, meningitis, urinary tract infections, and middle ear infections. Toxicity is low but there is sometimes damage to kidney and nerve cells. The route of administration is parenteral, oral, or topical to the ear or eye. Oral preparations are not used for systemic infections because the drug is poorly absorbed from the intestinal tract.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
pol·y·myx·in
(pol'ē-mik'sin),A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus), an organism found in water and soils and obtainable as a crystalline hydrochloride; all are polypeptides containing various amino acids and a branched-chain fatty acid, usually (+)-6-methyloctanoic acid. There are several polymyxins, (for example, designated A, B1, C, D, E, M, T), which are about equally effective against gram-negative bacteria, but which differ in toxicity, polymyxin E (colistin) and polymyxin B being the least toxic.
See also: colistimethate sodium.
See also: colistimethate sodium.
Farlex Partner Medical Dictionary © Farlex 2012
polymyxin
(pŏl′ē-mĭk′sĭn)n.
Any of various mainly toxic antibiotics derived from strains of the soil bacterium Bacillus polymyxa and used to treat various infections with gram-negative bacteria.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
pol·y·myx·in
(P) (pol'ē-mik'sin)A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa, an organism found in water and soils and obtainable as a crystalline hydrochloride.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
pol·y·myx·in
(pol'ē-mik'sin)A mixture of antibiotic substances obtained from cultures of Bacillus polymyxa (B. serosporus).
Medical Dictionary for the Dental Professions © Farlex 2012
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