Medical term:

fibrinogen

thrombin

[throm´bin]

1. the activated form of coagulation factor II (prothrombin), which catalyzes the conversion of fibrinogen to fibrin.

2. a preparation of this compound prepared from prothrombin of bovine origin, used as a topical hemostatic.

thrombin time (TT) the time required for plasma fibrinogen to form thrombin: exogenous thrombin is added to citrated plasma and the time to clot formation is measured. Prolonged TT is seen with abnormalities of fibrinogen and in the presence of heparin or degradation products of fibrin or fibrinogen.

throm·bin

(throm'bin),

1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).

2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.

Synonym(s): factor IIa, fibrinogenase, thrombase, thrombosin

Farlex Partner Medical Dictionary © Farlex 2012

thrombin

(thrŏm′bĭn)

A protease in blood that facilitates blood clotting by converting fibrinogen to fibrin.

thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.

throm·bin

(throm'bin)

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

thrombin

An enzyme in the blood that converts fibrinogen to fibrin, thus forming a blood clot.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

thrombin

see BLOOD CLOTTING.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Thrombin

Thrombin is a protein produced by the body. It is a specific clotting factor that plays an important role in the blood clotting process.

Mentioned in: Anticoagulant and Antiplatelet Drugs, Fibrinogen Test, Prothrombin Time

throm·bin

(throm'bin)

1. An enzyme (proteinase), formed in shed blood, which converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase.

2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting; used as a topical hemostatic for capillary bleeding in general and plastic surgical procedures.
Synonym(s): factor IIa.

Medical Dictionary for the Dental Professions © Farlex 2012

fibrinogen

[fi-brin´o-jen]

a high-molecular-weight protein in the blood plasma that by the action of thrombin is converted into fibrin; called also factor i. In the clotting mechanism, fibrin threads form a meshwork for the basis of a blood clot. Most of the fibrinogen in the circulating blood is formed in the liver. Normal quantities of fibrinogen in the plasma vary from 100 to 700 mg per 100 ml of plasma.

Commercial preparations of human fibrinogen are used to restore blood fibrinogen levels to normal after extensive surgery, or to treat diseases and hemorrhagic conditions that are complicated by afibrinogenemia.

fibrinogen degradation products fragments of fibrinogen or fibrin degraded by plasmin, which are found in the serum and urine of patients with disseminated intravascular coagulation (DIC) and in the urine of patients who have had renal transplants.

fi·brin·o·gen

(fī-brin'ō-jen),

A globulin of the blood plasma converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and is defective in dysfibrinogenemia.

Farlex Partner Medical Dictionary © Farlex 2012

fibrinogen

(fī-brĭn′ə-jən)

A protein in the blood plasma that is essential for the coagulation of blood and is converted to fibrin by the action of thrombin in the presence of ionized calcium.

fi′bri·nog′e·nous (fī′brə-nŏj′ə-nəs) adj.

fibrinogen

Coagulation factor I, factor I Hematology A soluble 340 kD plasma glycoprotein required for normal platelet function and wound healing; it is converted into fibrin in the common pathway of coagulation, and provides physical scaffolding for permanent hemostatic plugs, which is orchestrated under thrombin's baton; fibrinogen is an 'acute phase reactant,' which may be markedly ↑ in various types of nonspecific stimuli–eg, inflammation, hemostatic stress, pregnancy, autoimmune diseases; it is ↑ in hyperfibrinogenemia; ↓ in afibrinogenemia

fi·brin·o·gen

(fī-brin'ō-jen)

A globulin of the blood plasma that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood; the only coagulable protein in the blood plasma of vertebrates; absent in afibrinogenemia and defective in dysfibrinogenemia.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

fibrinogen

A protein in the blood that is converted to FIBRIN by the action of THROMBIN in the presence of ionized calcium, thereby bringing about coagulation of blood.

fibrinogen

fibrin

a large, soluble protein found in BLOOD PLASMA that is formed in the liver and is converted to insoluble fibrin by the enzyme thrombin during the process of BLOOD CLOTTING.

Fibrinogen

A type of blood protein called a globulin that interacts with thrombin to form fibrin.

Mentioned in: Prothrombin Time

fi·brin·o·gen

(fī-brin'ō-jen)

A globulin of blood plasma converted into fibrin by action of thrombin in presence of ionized calcium to coagulate blood; the only coagulable protein in the blood plasma of vertebrates; it is absent in afibrinogenemia and defective in dysfibrinogenemia.

Patient discussion about fibrinogen

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More discussions about fibrinogen

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