Medical term:
pseudohermaphroditism
pseudohermaphroditism
[soo″do-her-maf´ro-dit-izm″]a congenital abnormality in which an individually is genetically and gonadally of one sex but has significant contradictions in the morphologic criteria of sex, often including ambiguous external genitalia. In female pseudohermaphroditism, the individual is a genetic and gonadal female with partial masculinization such as an enlarged clitoris resembling a penis and labia majora resembling a scrotum. In male pseudohermaphroditism, the individual is a genetic and gonadal male with feminization or incomplete masculinization, including a small penis, perineal hypospadias, and a scrotum that lacks testes. Pseudohermaphroditism is not to be confused with hermaphroditism, in which the individual has both ovarian and testicular tissue.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
pseu·do·her·maph·ro·dit·ism
(sū'dō-hĕr-maf'rō-dīt-izm'),A state in which the person is of an unambiguous gonadal sex (that is, possesses either testes or ovaries) but has ambiguous external genitalia. Compare: steroid 5α-reductase.
Synonym(s): false hermaphroditism
Farlex Partner Medical Dictionary © Farlex 2012
pseudohermaphroditism
Endocrinology A state in which a person has the gonadal tissue of one sex, but the wiring, plumbing, and/or chassis of the opposite sex. See Female pseudohermaphroditism, Male pseudohermaphroditism. Cf Hermaphroditism, Intersex, Virilization. Pseudohermaphroditism
Female pseudohermaphroditism A condition affecting a genotypic–46, XX female with ovaries, caused by a relative excess of androgen in utero, resulting in equivocal or masculinized genital duct derivatives, ie external genitalia and/or a male phenotype with genital ambiguity and/or virilization Etiology
.1. Adrenogenital syndrome Defects of 21-hydroxylase, 11-β-hydroxylase or 3-β-hydroxysteroid dehydrogenase, or delta 5-4 isomerase deficiency, resulting in ↑ androgenic intermediates.
2. Maternal ingestion of progestins or androgens and three maternal virilizing tumors–eg, luteoma of pregnancy
Male pseudohermaphroditism, A condition affecting a genotypic–46, XY male with testes, caused by a relative deficiency of androgen in utero, resulting in a phenotypic female with ambiguous genitalia Etiology 1. Gonadal defects Testicular regression syndrome, persistent müllerian duct origin, Leydig cell agenesis and defects in testosterone synthesis 2. End-organ defects Testicular feminization or androgen insensitivity syndrome, incomplete androgen insensitivity syndrome and 5-α reductase deficiency. See Testicular feminization.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
pseu·do·her·maph·ro·dit·ism
(sū'dō-hĕr-maf'rō-di-tizm)A state in which the person is of an unambiguous gonadal sex (i.e., possesses either testes or ovaries) but has ambiguous external genitalia.
Synonym(s): false hermaphroditism.
Synonym(s): false hermaphroditism.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
pseudohermaphroditism
A congenital abnormality of the GENITALIA in which they resemble those of the opposite sex. The testes and ovaries (gonads) are, however, those of the genetically correct sex.Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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